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How and where to order Aromasin (Exemestane) 25 mg tablets online on the Pomperaug Plastic Surgery website:

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Indications and usage:

Aromasin (Exemestane) is an aromatase inhibitor indicated for:

  • adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to Aromasin for completion of a total of five consecutive years of adjuvant hormonal therapy.
  • treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
  • bodybuilding to raise luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels.
  • counteracting gynecomastia as well as fat and water retention due to testosterone doping.


    Dosage and administration:

    Recommended dose: one 25 mg exemestane tablet once daily after a meal.


    Dosage forms and strengths:

    Aromasin (Exemestane) tablets 25 mg.


    Overdosage:

    Clinical trials have been conducted with exemestane given as a single dose to healthy female volunteers at doses as high as 800 mg and daily for 12 weeks to postmenopausal women with advanced breast cancer at doses as high as 600 mg. These dosages were well tolerated. There is no specific antidote to overdosage and treatment must be symptomatic. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated.

    A male child (age unknown) accidentally ingested a 25-mg tablet of exemestane. The initial physical examination was normal, but blood tests performed 1 hour after ingestion indicated leucocytosis (WBC 25000/mm3 with 90% neutrophils). Blood tests were repeated 4 days after the incident and were normal. No treatment was given.

    In mice, mortality was observed after a single oral dose of exemestane of 3200 mg/kg, the lowest dose tested (about 640 times the recommended human dose on a mg/m2 basis). In rats and dogs, mortality was observed after single oral doses of exemestane of 5000 mg/kg (about 2000 times the recommended human dose on a mg/m2 basis) and of 3000 mg/kg (about 4000 times the recommended human dose on a mg/m2 basis), respectively.

    Convulsions were observed after single doses of exemestane of 400 mg/kg and 3000 mg/kg in mice and dogs (approximately 80 and 4000 times the recommended human dose on a mg/m2 basis), respectively.


    Contraindications:

    Patients with a known hypersensitivity to the drug or to any of the excipients.


    Warnings and precautions:

  • Reductions in bone mineral density (BMD) over time are seen with exemestane use.
  • Routine assessment of 25-hydroxy Vitamin D levels prior to the start of aromatase inhibitor treatment should be performed.
  • Embryo-fetal toxicity: can cause fetal harm. Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception.


    Adverse reactions, side effects:

  • Early breast cancer: adverse reactions occurring in >= 10% of patients in any treatment group were hot flushes, fatigue, arthralgia, headache, insomnia, increased sweating. Discontinuation rates due to AEs were similar between Aromasin and tamoxifen. Incidences of cardiac ischemic events (myocardial infarction, angina, and myocardial ischemia) were exemestane 1.6%, tamoxifen 0.6%. Incidence of cardiac failure: Aromasin (Exemestane) 0.4%, tamoxifen 0.3% (6, 6.1).

  • Advanced breast cancer: most common adverse reactions were mild to moderate and included hot flushes, nausea, fatigue, increased sweating, increased appetite.

    To report suspected adverse reactions, contact Pfizer Inc. or your local FDA.


    Drug interactions:

    Strong CYP 3A4 inducers: concomitant use of strong CYP 3A4 inducers decreases exemestane exposure. Increase the Aromasin (Exemestane) dose to 50 mg.

    Related medications:

  • Arimidex 1 mg tablets
  • Premarin tablets


    Use in specific populations:

    Lactation

    Advise not to breastfeed.

    Pediatric use

    Safety and effectiveness in pediatric patients have not been established.

    Hepatic impairment

    The AUC of exemestane was increased in subjects with moderate or severe hepatic impairment (Childs-Pugh B or C). However, based on experience with exemestane at repeated doses up to 200 mg daily that demonstrated a moderate increase in non life-threatening adverse reactions, dosage adjustment does not appear to be necessary.

    Renal impairment

    The AUC of exemestane was increased in subjects with moderate or severe renal impairment (creatinine clearance < 35 mL/min/1.73 m2). However, based on experience with exemestane at repeated doses up to 200 mg daily that demonstrated a moderate increase in non life-threatening adverse reactions, dosage adjustment does not appear to be necessary.


    Patient counseling information:

    Bone effects

    Advise patients that Aromasin lowers the level of estrogen in the body. This may lead to reduction in bone mineral density (BMD) over time. The lower the BMD, the greater the risk of osteoporosis and fracture.

    Other estrogen-containing agents

    Advise patients that they should not take estrogen-containing agents while they are taking Exemestane (Aromasin) tablets as these could interfere with its pharmacologic action.

    Use in premenopausal women

    Advise patients that this medication is not for use for the treatment of breast cancer in premenopausal women.

    Embryo-fetal toxicity

    Advise pregnant women and females of reproductive potential that exposure during pregnancy or within 1 month prior to conception can result in fetal harm. Advise females to inform their healthcare provider of a known or suspected pregnancy.

    Advise females of reproductive potential to use effective contraception while taking Aromasin and for 1 month after the last dose.

    Lactation

    Advise women not to breastfeed during treatment with this medicine and for 1 month after the last dose.


    Where to buy exemestane online:

    To purchase Aromasin (Exemestane) 25 mg tablets from reliable online pharmacies and drugstores at low prices please use resources described above on this webpage.


    Here is a list of popular medications containing exemestane as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Aromasin
  • Tablets; Oral; Exemestane 25 mg
  • Pfizer
  • LF Asia Distribution
  • O.P.D. Laboratories
  • The Glory Medicina
  • Zuellig Pharma
  • Exedrol
  • Tablets; Oral; Exemestane 25 mg
  • Balkan Pharmaceuticals
  • Liquid Aromasin
  • Injectable; Injection; Exemestane 10 mg / ml
  • Pfizer
  • Mestane
  • Tablets; Oral; Exemestane 25 mg
  • Farma Group
  • Nateran
  • Tablets, Film-Coated; Oral; Exemestane 25 mg
  • Synthon
  • XTane
  • Tablets; Oral; Exemestane 25 mg
  • Natco Pharma


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